Nancy McKeon was born in Westbury, New York to Don and Barbara McKeon, began modeling baby clothes for the Sears catalog at the age of two and she and her brother did over sixty-five commercials in seven years. When her brother, Philip McKeon, won a role on the TV series, Alice (1976), the family moved to Los Angeles.
1993的《X档案》中的莫探员令大卫·杜楚尼终于大展鸿图,五年后出任电影版《X档案:征服未来》的男主角。