Luke Austin Halpin was born in Astoria, Queens, New York, the youngest of three children of Helen Joan (Szczepanski) and Eugene A. Halpin. His father was of Irish and German descent, and his maternal grandparents were Polish.
95年的时候因为在四季喜剧电视剧《Cybill》里主演Maryann Thorpe而走红，这个角色让她获得2个金球奖提名，三个艾美奖提名一个艾美奖喜剧类最佳女配角奖，获得96年的美国喜剧奖，获得95年的屏幕演员工会奖最佳喜剧女演员奖。《Cybill》这部电视剧有点类似于当年的宋飞正传，女主角是由Cybill Shepherd自己演自己。
