Nicholas Brendon was born three minutes after his identical twin brother, actor Kelly Donovan on April 12, 1971 in Los Angeles, California. He attended Chatsworth High School, where he struggled with stuttering but was also a starter on the baseball team. He had dreams of playing for the L.A. Dodgers, but had to pursue other options when he hurt his arm about a year after graduating high school.
父亲是中国人,母亲是法国人。五岁时搬家至加拿大。在成为演员之前,她在巴黎做跑道模特。