Karen Duffy was born on May 23, 1961 in New York City, New York, USA. She is an actress and producer, known for Dumb and Dumber (1994), Fantastic Mr. Fox (2009) and Last Action Hero (1993). She has been married to John Lambros since February 28, 1997. They have one child.
She is currently engaged, as of 2008, to fellow actor James Spader of The Practice and Boston Legal. On August 31, 2008, she gave birth to her first child, a son by James Spader.